Comparsion of Wild and Mutant Targets

Name of the drug	Targets Name	Amino acids sites at interacting residues	Docking score (Wild)			Docking score (Mutant)
Name of the drug	Targets Name	Amino acids sites at interacting residues	Amino Acid	Binding Score	2D structure	Amino Acid	Binding Score	2D structure
Tolcapone	SNCA	30	A	-5.8		P	-5.6
		46	E			K	-5.6
		50	H			Q	-5.8
		51	G			D	-5.9
		53	A			T	-6.0
		53	A			V	-5.8
	NURR1	103	H	-7.2		R	-7.5
	LRRK2	551	N	-7.4		K	-8.2
		1373	V			M	-8.1
		1441	R			G	-8.3
		1441	R			C	-8.3
		1628	R			P	-8.4
		1699	Y			C	-7.8
		2019	G			S	-7.7
		2020	I			T	-7.8
	PINK1	240	E	-7.2		K	-7.7
		271	H			Q	-8.3
		309	G			D	-8.3
		347	L			P	-7.2
		409	G			V	-7.7
		369	L			P	-7.9
		388	C			R	-7.2
		417	E			G	-7.9
	Parkin	161	K	-7.2		N	-8.2
		256	R			C	-8.2
		275	R			W	-8.4
		289	C			G	-8.1
		394	D			N	-8.3
		402	R			C	-8.1
		430	G			D	-8.1
		415	T			N	-8.3
	GSK3B	7	V	-7.6		I	-8.4
	UCHL1	7	E	-8.4		A	-7.2
	UCHL1	93	I	-8.4		M	-6.9
	DJ1	10	L	-7.6		P	-6.5
		26	M			I	-7.0
		104	A			T	-5.6
		107	A			P	-6.4
		149	D			A	-7
		163	E			K	-6.5
		166	L			P	-6.5
		172	L			Q	-6.5
	ATP13A2	49	G	-7.9		S	-7.7
		504	G			R	-8.6
		578	V			G	-7.7
		877	G			R	-7.7
Safinamide	SNCA	30	A	-5.9		P	-5.6
		46	E			K	-5
		50	H			Q	-5.6
		51	G			D	-5.5
		53	A			T	-5.5
		53	A			V	-4.9
	NURR1	103	H	-6.9		R	-7
	LRRK2	551	N	-7.2		K	-7.4
		1373	V			M	-7.3
		1441	R			G	-7.2
		1441	R			C	-7.5
		1628	R			P	-8.6
		1699	Y			C	-6.9
		2019	G			S	-7.7
		2020	I			T	-7.2
	PINK1	240	E	-7.7		K	-7.3
		271	H			Q	-7.7
		309	G			D	-7.1
		347	L			P	-7.2
		409	G			V	-7.4
		369	L			P	-8.2
		388	C			R	-7.5
		417	E			G	-7.6
	Parkin	161	K	-7.8		N	-7.8
		256	R			C	-7.1
		275	R			W	-7.3
		289	C			G	-7.2
		394	D			N	-6.9
		402	R			C	-6.8
		430	G			D	-6.9
		415	T			N	-6.5
	GSK3B	7	V	-7.7		I	-7.1
	UCHL1	7	E	-8.8		A	-7.1
	UCHL1	93	I	-8.8		M	-6.9
	DJ1	10	L	-6.2		P	-6.4
		26	M			I	-6.6
		104	A			T	-6
		107	A			P	-6.2
		149	D			A	-5.5
		163	E			K	-6.4
		166	L			P	-6.3
		172	L			Q	-6.3
	ATP13A2	49	G	-7.3		S	-7.6
		504	G			R	-7.7
		578	V			G	-7.5
		877	G			R	-7.4
Droxidopa	SNCA	30	A	-5.1		P	-4.8
		46	E			K	-5.1
		50	H			Q	-5.1
		51	G			D	-4.8
		53	A			T	-5.1
		53	A			V	-5.1
	NURR1	103	H	-6		R	-5.7
	LRRK2	551	N	-7.1		K	-6.1
		1373	V			M	-6
		1441	R			G	-6.4
		1441	R			C	-6.5/td>
		1628	R			P	-6.5
		1699	Y			C	-6.4
		2019	G			S	-6.9
		2020	I			T	-6.1
	PINK1	240	E	-6		K	-6.2
		271	H			Q	-6.3
		309	G			D	-6.2
		347	L			P	-5.6
		409	G			V	-5.8
		369	L			P	-6
		388	C			R	-6.1
		417	E			G	-5.4
	Parkin	161	K	-6.8		N	-6.7
		256	R			C	-6.6
		275	R			W	-6.4
		289	C			G	-6
		394	D			N	-6.7
		402	R			C	-6.4
		430	G			D	-6.5
		415	T			N	-6.1
	GSK3B	7	V	-6.3		I	-5.9
	UCHL1	7	E	-7.1		A	-6.2
	UCHL1	93	I	-7.1		M	-6.1
	DJ1	10	L	-5.2		P	-4.9
		26	M			I	-5.6
		104	A			T	-5.2
		107	A			P	-5.2
		149	D			A	-5.5
		163	E			K	-5.4
		166	L			P	-5.3
		172	L			Q	-6
	ATP13A2	49	G	-6.5		S	-6.8
		504	G			R	-7.6
		578	V			G	-6.5
		877	G			R	-6
Ropinirole	SNCA	30	A	-3.9		P	-4
		46	E			K	-4.2
		50	H			Q	-3.9
		51	G			D	-4.4
		53	A			T	-4.0
		53	A			V	-4.1
	NURR1	103	H	-5.5		R	-5.8
	LRRK2	551	N	-5.4		K	-6.4
		1373	V			M	-5.3
		1441	R			G	-5.5
		1441	R			C	-5.5/td>
		1628	R			P	-5.7
		1699	Y			C	-5.2
		2019	G			S	-5.4
		2020	I			T	-5.3
	PINK1	240	E	-5.5		K	-4
		271	H			Q	-4.1
		309	G			D	-4.2
		347	L			P	-5.4
		409	G			V	-5.6
		369	L			P	-5.4
		388	C			R	-5.1
		417	E			G	-4.8
	Parkin	161	K	-5.1		N	-5.6
		256	R			C	-5.7
		275	R			W	-5.7
		289	C			G	-5.3
		394	D			N	-4.9
		402	R			C	-5.7
		430	G			D	-4.9
		415	T			N	-4.8
	GSK3B	7	V	-6.3		I	-6.1
	UCHL1	7	E	-6.2		A	-6
	UCHL1	93	I	-6.2		M	-5.5
	DJ1	10	L	-5.7		P	-5.4
		26	M			I	-4.9
		104	A			T	-4
		107	A			P	-5.3
		149	D			A	-5.2
		163	E			K	-5
		166	L			P	-5.4
		172	L			Q	-5.4
	ATP13A2	49	G	-6.2		S	-6.5
		504	G			R	-5.9
		578	V			G	-6.0
		877	G			R	-6.3
Carbidopa	SNCA	30	A	-5.1		P	-4.2
		46	E			K	-5.5
		50	H			Q	-5.3
		51	G			D	-5.5
		53	A			T	-5.3
		53	A			V	-5.3
	NURR1	103	H	-5.7		R	-5.7
	LRRK2	551	N	-6.9		K	-6.4
		1373	V			M	-6.3
		1441	R			G	-6.2
		1441	R			C	-6.1/td>
		1628	R			P	-6.1
		1699	Y			C	-6.9
		2019	G			S	-6.2
		2020	I			T	-7.1
	PINK1	240	E	-5.5		K	-5.3
		271	H			Q	-6.6
		309	G			D	-6.4
		347	L			P	-5.6
		409	G			V	-5.7
		369	L			P	-5.5
		388	C			R	-5.4
		417	E			G	-6.3
	Parkin	161	K	-6.9		N	-7.0
		256	R			C	-6.9
		275	R			W	-6.9
		289	C			G	-6.3
		394	D			N	-6.9
		402	R			C	-6.9
		430	G			D	-6.5
		415	T			N	-6.9
	GSK3B	7	V	-6.2		I	-7.6
	UCHL1	7	E	-8		A	-6.4
	UCHL1	93	I	-8		M	-6.7
	DJ1	10	L	-5.4		P	-5.2
		26	M			I	-5.7
		104	A			T	-5.3
		107	A			P	-5.3
		149	D			A	-5.6
		163	E			K	-5.6
		166	L			P	-5.1
		172	L			Q	-5.2
	ATP13A2	49	G	-6.6		S	-6.5
		504	G			R	-6.5
		578	V			G	-6.4
		877	G			R	-6.5
Amantadine	SNCA	30	A	-5.9		P	-5.9
		46	E			K	-5.9
		50	H			Q	-5.9
		51	G			D	-5.9
		53	A			T	-5.9
		53	A			V	-5.9
	NURR1	103	H	-6.8		R	-6.8
	LRRK2	551	N	-7.8		K	-7.8
		1373	V			M	-7.7
		1441	R			G	-8.8
		1441	R			C	-9/td>
		1628	R			P	-7.8
		1699	Y			C	-7.6
		2019	G			S	-7.3
		2020	I			T	-7.8
	PINK1	240	E	-6.8		K	-7.5
		271	H			Q	-7.7
		309	G			D	-8.6
		347	L			P	-6.4
		409	G			V	-7.0
		369	L			P	-7.7
		388	C			R	-7.5
		417	E			G	-7.0
	Parkin	161	K	-7.8		N	-7.2
		256	R			C	-7.8
		275	R			W	-7.8
		289	C			G	-7.2
		394	D			N	-7.0
		402	R			C	-7.8
		430	G			D	-7.4
		415	T			N	-6.7
	GSK3B	7	V	-8		I	-7.7
	UCHL1	7	E	-7.8		A	-6.8
	UCHL1	93	I	-7.8		M	-6.9
	DJ1	10	L	-6.6		P	-6.7
		26	M			I	-8.2
		104	A			T	-5.9
		107	A			P	-8.2
		149	D			A	-8.2
		163	E			K	-8.2
		166	L			P	-6.7
		172	L			Q	-6.8
	ATP13A2	49	G	-8		S	-8.4
		504	G			R	-7.7
		578	V			G	-8.0
		877	G			R	-7.4
Rivastigmine	SNCA	30	A	-4.6		P	-4.5
		46	E			K	-4.3
		50	H			Q	-4.2
		51	G			D	-4.3
		53	A			T	-4.2
		53	A			V	-4.4
	NURR1	103	H	-5.4		R	-5.7
	LRRK2	551	N	-5.9		K	-6.4
		1373	V			M	-6.3
		1441	R			G	-6.4
		1441	R			C	-6/td>
		1628	R			P	-5.8
		1699	Y			C	-5.3
		2019	G			S	-5.7
		2020	I			T	-6
	PINK1	240	E	-5.4		K	-5.5
		271	H			Q	-5.6
		309	G			D	-6.0
		347	L			P	-5.9
		409	G			V	-6.2
		369	L			P	-6.4
		388	C			R	-6.3
		417	E			G	-5.7
	Parkin	161	K	-6		N	-5.7
		256	R			C	-5.6
		275	R			W	-5.9
		289	C			G	-5.7
		394	D			N	-6.2
		402	R			C	-6
		430	G			D	-5.8
		415	T			N	-6.0
	GSK3B	7	V	-5.8		I	-5.9
	UCHL1	7	E	-6		A	-6
	UCHL1	93	I	-6		M	-5.9
	DJ1	10	L	-6		P	-5.3
		26	M			I	-5.3
		104	A			T	-4.5
		107	A			P	-5.4
		149	D			A	-5.3
		163	E			K	-5
		166	L			P	-5.3
		172	L			Q	-5.3
	ATP13A2	49	G	-6.5		S	-5.9
		504	G			R	-6.5
		578	V			G	-6.1
		877	G			R	-6.3
Selegiline	SNCA	30	A	-4.2		P	-3.4
		46	E			K	-4.2
		50	H			Q	-3.8
		51	G			D	-4.0
		53	A			T	-4.0
		53	A			V	-3.9
	NURR1	103	H	-4.3		R	-4
	LRRK2	551	N	-5.2		K	-5.4
		1373	V			M	-5.3
		1441	R			G	-5.2
		1441	R			C	-5.6/td>
		1628	R			P	-5.4
		1699	Y			C	-5.8
		2019	G			S	-4.2
		2020	I			T	-5.2
	PINK1	240	E	-5.1		K	-4.4
		271	H			Q	-5
		309	G			D	-6.2
		347	L			P	-5
		409	G			V	-5.1
		369	L			P	-5.7
		388	C			R	-5.8
		417	E			G	-5.0
	Parkin	161	K	-4.7		N	-5.4
		256	R			C	-5.3
		275	R			W	-5.3
		289	C			G	-4.2
		394	D			N	-5.4
		402	R			C	-4.6
		430	G			D	-5.8
		415	T			N	-4.4
	GSK3B	7	V	-5.3		I	-5.6
	UCHL1	7	E	-5.4		A	-4.9
	UCHL1	93	I	-5.4		M	-5
	DJ1	10	L	-4.4		P	-4.2
		26	M			I	-4.5
		104	A			T	-4.9
		107	A			P	-5
		149	D			A	-5.3
		163	E			K	-4.9
		166	L			P	-4.5
		172	L			Q	-4.4
	ATP13A2	49	G	-5.5		S	-5.4
		504	G			R	-5.6
		578	V			G	-5.7
		877	G			R	-5.5
Foslevodopa	SNCA	30	A	-5.3		P	-5.2
		46	E			K	-5.2
		50	H			Q	-5.3
		51	G			D	-5.1
		53	A			T	-5.0
		53	A			V	-5.1
	NURR1	103	H	-4.3		R	-4
	LRRK2	551	N	-6		K	-6.7
		1373	V			M	-6.2
		1441	R			G	-6.1
		1441	R			C	-6.6/td>
		1628	R			P	-6.1
		1699	Y			C	-6.2
		2019	G			S	-6.2
		2020	I			T	-6.8
	PINK1	240	E	-6.4		K	-6.2
		271	H			Q	-6.4
		309	G			D	-5.6
		347	L			P	-6
		409	G			V	-6.5
		369	L			P	-6.5
		388	C			R	-6.1
		417	E			G	-6.5
	Parkin	161	K	-6.6		N	-6.4
		256	R			C	-6.6
		275	R			W	-6.4
		289	C			G	-5.8
		394	D			N	-6.3
		402	R			C	-6.3
		430	G			D	-6.1
		415	T			N	-6.5
	GSK3B	7	V	-6.1		I	-7.3
	UCHL1	7	E	-7.6		A	-6.1
	UCHL1	93	I	-7.6		M	-6.7
	DJ1	10	L	-6.3		P	-5.4
		26	M			I	-5.9
		104	A			T	-5.2
		107	A			P	-5.9
		149	D			A	-5.9
		163	E			K	-5.5
		166	L			P	-5.4
		172	L			Q	-5.5
	ATP13A2	49	G	-7.3		S	-6.5
		504	G			R	-6.3
		578	V			G	-6.5
		877	G			R	-6.5
Entacapone	SNCA	30	A	-5.1		P	-5.2
		46	E			K	-5.1
		50	H			Q	-5.0
		51	G			D	-5.1
		53	A			T	-5.1
		53	A			V	-5.2
	NURR1	103	H	-6.1		R	-6.9
	LRRK2	551	N	-6.9		K	-7.7
		1373	V			M	-7.7
		1441	R			G	-7.4
		1441	R			C	-7.5/td>
		1628	R			P	-7.7
		1699	Y			C	-7.1
		2019	G			S	-6.8
		2020	I			T	-7.1
	PINK1	240	E	-6.1		K	-7
		271	H			Q	-6.6
		309	G			D	-6.0
		347	L			P	-6.4
		409	G			V	-5.9
		369	L			P	-6.6
		388	C			R	-6.5
		417	E			G	-6.6
	Parkin	161	K	-6.8		N	-7.4
		256	R			C	-7.3
		275	R			W	-7.1
		289	C			G	-
		394	D			N	-6.6
		402	R			C	-7.3
		430	G			D	-6.8
		415	T			N	-7.3
	GSK3B	7	V	-7		I	-6.6
	UCHL1	7	E	-7.1		A	-6.7
	UCHL1	93	I	-7.1		M	-6.4
	DJ1	10	L	-7		P	-5.7
		26	M			I	-9
		104	A			T	-5.2
		107	A			P	-5.9
		149	D			A	-5.9
		163	E			K	-5.4
		166	L			P	-5.7
		172	L			Q	-5.7
	ATP13A2	49	G	-6.4		S	-6.6
		504	G			R	-6.8
		578	V			G	-6.9
		877	G			R	-6.6
Benserazide	SNCA	30	A	-5.1		P	-5.2
		46	E			K	-5.1
		50	H			Q	-5.0
		51	G			D	-5.1
		53	A			T	-5.1
		53	A			V	-5.2
	NURR1	103	H	-6.1		R	-6.9
	LRRK2	551	N	-6.9		K	-7.7
		1373	V			M	-7.7
		1441	R			G	-7.4
		1441	R			C	-7.5/td>
		1628	R			P	-7.7
		1699	Y			C	-7.1
		2019	G			S	-6.8
		2020	I			T	-7.1
	PINK1	240	E	-6.1		K	-7
		271	H			Q	-6.6
		309	G			D	-6.0
		347	L			P	-6.4
		409	G			V	-5.9
		369	L			P	-6.6
		388	C			R	-6.5
		417	E			G	-6.6
	Parkin	161	K	-6.8		N	-7.4
		256	R			C	-7.3
		275	R			W	-7.1
		289	C			G	-
		394	D			N	-6.6
		402	R			C	-7.3
		430	G			D	-6.8
		415	T			N	-7.3
	GSK3B	7	V	-7		I	-6.6
	UCHL1	7	E	-7.1		A	-6.7
	UCHL1	93	I	-7.1		M	-6.4
	DJ1	10	L	-7		P	-5.7
		26	M			I	-9
		104	A			T	-5.2
		107	A			P	-5.9
		149	D			A	-5.9
		163	E			K	-5.4
		166	L			P	-5.7
		172	L			Q	-5.7
	ATP13A2	49	G	-6.4		S	-6.6
		504	G			R	-6.8
		578	V			G	-6.9
		877	G			R	-6.6
Trihexyphenidyl	SNCA	30	A	-7.5		P	-7.4
		46	E			K	-7.4
		50	H			Q	-7.4
		51	G			D	-7.3
		53	A			T	-7.4
		53	A			V	-7.4
	NURR1	103	H	-8.8		R	-8.7
	LRRK2	551	N	-10.3		K	-10.8
		1373	V			M	-10
		1441	R			G	-10.4
		1441	R			C	-9.8/td>
		1628	R			P	-9.8
		1699	Y			C	-10.3
		2019	G			S	-10
		2020	I			T	-9.8
	PINK1	240	E	-10.1		K	-11.3
		271	H			Q	-11.3
		309	G			D	-11.3
		347	L			P	-9.9
		409	G			V	-10.5
		369	L			P	-10.5
		388	C			R	-10.3
		417	E			G	-10.5
	Parkin	161	K	-10.1		N	-10.1
		256	R			C	-10.1
		275	R			W	-10
		289	C			G	-9.5
		394	D			N	-10
		402	R			C	-10.1
		430	G			D	-9.4
		415	T			N	-9.4
	GSK3B	7	V	-9.8		I	-9.3
	UCHL1	7	E	-10.3		A	-8.9
	UCHL1	93	I	-10.3		M	-8.9
	DJ1	10	L	-8.4		P	-8.3
		26	M			I	-9
		104	A			T	-8.3
		107	A			P	-8.3
		149	D			A	-9.0
		163	E			K	-9
		166	L			P	-8.2
		172	L			Q	-8.3
	ATP13A2	49	G	-10		S	-11.3
		504	G			R	-10.7
		578	V			G	-10.7
		877	G			R	-9.3
Procyclidine	SNCA	30	A	-7.4		P	-7
		46	E			K	-7.3
		50	H			Q	-7.3
		51	G			D	-7.3
		53	A			T	-7.3
		53	A			V	-7.3
	NURR1	103	H	-8.7		R	-9.4
	LRRK2	551	N	-9.8		K	-9.5
		1373	V			M	-9.3
		1441	R			G	-9.5
		1441	R			C	-10/td>
		1628	R			P	-10.5
		1699	Y			C	-9.5
		2019	G			S	-9.8
		2020	I			T	-10
	PINK1	240	E	-8.7		K	-10.8
		271	H			Q	-10.8
		309	G			D	-10.8
		347	L			P	-8.7
		409	G			V	-9.9
		369	L			P	-9.9
		388	C			R	-9.8
		417	E			G	-9.9
	Parkin	161	K	-10		N	-9.8
		256	R			C	-9.9
		275	R			W	-9.8
		289	C			G	-9.1
		394	D			N	-10
		402	R			C	-10
		430	G			D	-9.1
		415	T			N	-10
	GSK3B	7	V	-9.6		I	-8.9
	UCHL1	7	E	-10.2		A	-8.8
	UCHL1	93	I	-10.2		M	-8.5
	DJ1	10	L	-9.8		P	-8.2
		26	M			I	-8.9
		104	A			T	-7.3
		107	A			P	-8.3
		149	D			A	-9.0
		163	E			K	-9.0
		166	L			P	-8.2
		172	L			Q	-8.3
	ATP13A2	49	G	-9.7		S	-10.8
		504	G			R	-10.5
		578	V			G	-10.5
		877	G			R	-9.2
Levodopa	SNCA	30	A	-4.9		P	-4.8
		46	E			K	-5
		50	H			Q	-4.9
		51	G			D	-5.1
		53	A			T	-5.1
		53	A			V	-4.7
	NURR1	103	H	-6		R	-5.8
	LRRK2	551	N	-5.5		K	-6.7
		1373	V			M	-6
		1441	R			G	-6.5
		1441	R			C	-6.2/td>
		1628	R			P	-6.4
		1699	Y			C	-6.2
		2019	G			S	-6.7
		2020	I			T	-6.6
	PINK1	240	E	-6		K	-6.4
		271	H			Q	-6.4
		309	G			D	-6.3
		347	L			P	-5.5
		409	G			V	-6.1
		369	L			P	-6.4
		388	C			R	-6.3
		417	E			G	-6.1
	Parkin	161	K	-6.8		N	-6.6
		256	R			C	-6.7
		275	R			W	-6.4
		289	C			G	-6.3
		394	D			N	-6
		402	R			C	-6.8
		430	G			D	-5.9
		415	T			N	-6.6
	GSK3B	7	V	-5.8		I	-5.6
	UCHL1	7	E	-6.2		A	-6.3
	UCHL1	93	I	-6.2		M	-6.0
	DJ1	10	L	-5.6		P	-5.2
		26	M			I	-5.6
		104	A			T	-4.8
		107	A			P	-5.2
		149	D			A	-5.4
		163	E			K	-5.6
		166	L			P	-5.2
		172	L			Q	-5.2
	ATP13A2	49	G	-6.5		S	-7.5
		504	G			R	-6.2
		578	V			G	-7.5
		877	G			R	-5.9
Cycrimine	SNCA	30	A	-8.1		P	-7.6
		46	E			K	-7.9
		50	H			Q	-7.9
		51	G			D	-7.9
		53	A			T	-7.9
		53	A			V	-7.9
	NURR1	103	H	-8.3		R	-8.2
	LRRK2	551	N	-10		K	-9.5
		1373	V			M	-9.5
		1441	R			G	-9.5
		1441	R			C	-9.6/td>
		1628	R			P	-10
		1699	Y			C	-10
		2019	G			S	-9.5
		2020	I			T	-9.6
	PINK1	240	E	-9.4		K	-11
		271	H			Q	-10.9
		309	G			D	-8.9
		347	L			P	-9.2
		409	G			V	-9.9
		369	L			P	-9.9
		388	C			R	-9.5
		417	E			G	-9.8
	Parkin	161	K	-9.8		N	-9.8
		256	R			C	-9.9
		275	R			W	-9.8
		289	C			G	-9.3
		394	D			N	-9.8
		402	R			C	-9.8
		430	G			D	-9.3
		415	T			N	-9.8
	GSK3B	7	V	-9.2		I	-9.1
	UCHL1	7	E	-11		A	-9.1
	UCHL1	93	I	-11		M	-9
	DJ1	10	L	-8		P	-8
		26	M			I	-8.9
		104	A			T	-8
		107	A			P	-8
		149	D			A	-9.0
		163	E			K	-8.9
		166	L			P	-7.9
		172	L			Q	-8
	ATP13A2	49	G	-10.1		S	-10.6
		504	G			R	-10.5
		578	V			G	-10.5
		877	G			R	-9.3
Istradefylline	SNCA	30	A	-5.6		P	-5.2
		46	E			K	-5.1
		50	H			Q	-5.4
		51	G			D	-4.9
		53	A			T	-5.5
		53	A			V	-5.4
	NURR1	103	H	-6.3		R	-6.3
	LRRK2	551	N	-6.6		K	-6.9
		1373	V			M	-6.7
		1441	R			G	-6.8
		1441	R			C	-6.9/td>
		1628	R			P	-6.7
		1699	Y			C	-6.8
		2019	G			S	-6.4
		2020	I			T	-6.8
	PINK1	240	E	-6.3		K	-5.7
		271	H			Q	-6.2
		309	G			D	-5.9
		347	L			P	-6.3
		409	G			V	-7.5
		369	L			P	-7.4
		388	C			R	-7
		417	E			G	-7.5
	Parkin	161	K	-6.8		N	-6.7
		256	R			C	-6.9
		275	R			W	-6.7
		289	C			G	-6.7
		394	D			N	-7.3
		402	R			C	-7
		430	G			D	-6.8
		415	T			N	-6.8
	GSK3B	7	V	-8		I	-7.3
	UCHL1	7	E	-7.3		A	-7.3
	UCHL1	93	I	-7.3		M	-7.2
	DJ1	10	L	-6.1		P	-5.9
		26	M			I	-7.4
		104	A			T	-6
		107	A			P	-6
		149	D			A	-6
		163	E			K	-6
		166	L			P	-6.1
		172	L			Q	-6
	ATP13A2	49	G	-7.4		S	-6.9
		504	G			R	-7.6
		578	V			G	-6.9
		877	G			R	-7.4
Pergolide	SNCA	30	A	-5.4		P	-5.2
		46	E			K	-5
		50	H			Q	-5.2
		51	G			D	-5.2
		53	A			T	-5.1
		53	A			V	-5.3
	NURR1	103	H	-6.2		R	-6.9
	LRRK2	551	N	-7.1		K	-7.1
		1373	V			M	-7.7
		1441	R			G	-7.3
		1441	R			C	-7.6/td>
		1628	R			P	-7.6
		1699	Y			C	-7.3
		2019	G			S	-7.2
		2020	I			T	-6.9
	PINK1	240	E	-6.2		K	-7.1
		271	H			Q	-6.5
		309	G			D	-6.6
		347	L			P	-6.9
		409	G			V	-7.9
		369	L			P	-7.8
		388	C			R	-7.1
		417	E			G	-7.9
	Parkin	161	K	-7.2		N	-7.1
		256	R			C	-7.2
		275	R			W	-7.2
		289	C			G	-7.1
		394	D			N	-7.2
		402	R			C	-7.2
		430	G			D	-7.2
		415	T			N	-7.2
	GSK3B	7	V	-7.3		I	-7.3
	UCHL1	7	E	-7.2		A	-7
	UCHL1	93	I	-7.2		M	-6.5
	DJ1	10	L	-7.1		P	-6.6
		26	M			I	-6.5
		104	A			T	-5.2
		107	A			P	-6.6
		149	D			A	-6.1
		163	E			K	-5.7
		166	L			P	-6.6
		172	L			Q	-6.4
	ATP13A2	49	G	-7.2		S	-7.4
		504	G			R	-7.5
		578	V			G	-7.5
		877	G			R	-6.9
Pramipexole	SNCA	30	A	-4.8		P	-4.6
		46	E			K	-4.1
		50	H			Q	-4.7
		51	G			D	-4.1
		53	A			T	-4.1
		53	A			V	-4.6
	NURR1	103	H	-5		R	-4.8
	LRRK2	551	N	-6		K	-5.7
		1373	V			M	-5.6
		1441	R			G	-5.7
		1441	R			C	-5.7/td>
		1628	R			P	-5.6
		1699	Y			C	-5.7
		2019	G			S	-5.9
		2020	I			T	-5.1
	PINK1	240	E	-5.4		K	-5.7
		271	H			Q	-5
		309	G			D	-5.0
		347	L			P	-5.2
		409	G			V	-5.4
		369	L			P	-5.8
		388	C			R	-5.3
		417	E			G	-5.5
	Parkin	161	K	-5.8		N	-5.5
		256	R			C	-5.8
		275	R			W	-6.2
		289	C			G	-6
		394	D			N	-5.7
		402	R			C	-5.9
		430	G			D	-6
		415	T			N	-6
	GSK3B	7	V	-5.7		I	-5.4
	UCHL1	7	E	-5.5		A	-5.8
	UCHL1	93	I	-5.5		M	-5.3
	DJ1	10	L	-4.9		P	-4.8
		26	M			I	-5.3
		104	A			T	-4.9
		107	A			P	-4.9
		149	D			A	-5.1
		163	E			K	-4.8
		166	L			P	-4.9
		172	L			Q	-4.9
	ATP13A2	49	G	-6.1		S	-5.7
		504	G			R	-5.8
		578	V			G	-5.7
		877	G			R	-5.8

Parkinson’s Disease Associated SNPs Database

Comparsion of Wild and Mutant Targets